Aasif Mandvi & Jon Stewart have it:
One of the hardest transitions that students have to make on the way to becoming a scientist is embracing the uncertainty of what you have to do. Science is a very weird endeavor. The philosophy of science explains why a scientist can never know whether they have the correct answer to a question; one can only know if they are wrong. Moreover, science is much more about defining a question, which means that we don’t even know what the right questions to ask are. Thus, being a scientist means that not only will you not know if you have the right answer, you won’t even know if you’re asking the right question.